Drug interactions
Captopril-hydrochlorothiazide + Heparin
Severity: Moderate
Captopril-hydrochlorothiazide and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Heparin can suppress aldosterone secretion, and ACE inhibitors also lower aldosterone, so together they may cause hyperkalemia. Risk is greater with renal impairment, diabetes or prolonged heparin use; the thiazide partly offsets this by wasting potassium.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Heparin belongs to Cardiovascular.
Why it happens
Heparin inhibits adrenal aldosterone synthesis, adding to reduced aldosterone from ACE inhibition and reducing renal potassium excretion.
What to do
Monitor serum potassium and renal function, particularly if heparin is given for more than a few days or in high-risk patients. Treat hyperkalemia and review the need for the ACE inhibitor if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Heparin?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Heparin can suppress aldosterone secretion, and ACE inhibitors also lower aldosterone, so together they may cause hyperkalemia. Risk is greater with renal impairment, diabetes or prolonged heparin use; the thiazide partly offsets this by wasting potassium.
How serious is the interaction between Captopril-hydrochlorothiazide and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and renal function, particularly if heparin is given for more than a few days or in high-risk patients. Treat hyperkalemia and review the need for the ACE inhibitor if it develops.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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