Drug interactions
Captopril-hydrochlorothiazide + Hydrocortisone
Severity: Moderate
Captopril-hydrochlorothiazide and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrocortisone has mineralocorticoid activity and promotes potassium excretion, which adds to the potassium loss caused by hydrochlorothiazide. This can lead to hypokalemia, particularly with higher or prolonged steroid doses.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from corticosteroid mineralocorticoid effect and thiazide diuresis.
What to do
Monitor serum potassium during combined use and supplement as needed, particularly with long-term or high-dose steroids.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Hydrocortisone?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrocortisone has mineralocorticoid activity and promotes potassium excretion, which adds to the potassium loss caused by hydrochlorothiazide. This can lead to hypokalemia, particularly with higher or prolonged steroid doses.
How serious is the interaction between Captopril-hydrochlorothiazide and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium during combined use and supplement as needed, particularly with long-term or high-dose steroids.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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