Drug interactions
Captopril-hydrochlorothiazide + Indacaterol inhaled
Severity: Moderate
Captopril-hydrochlorothiazide and Indacaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indacaterol, a long-acting beta-2 agonist, can lower serum potassium and may add to potassium loss from hydrochlorothiazide. At higher doses this may contribute to hypokalemia and electrocardiographic changes.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 mediated cellular potassium uptake adds to thiazide-induced renal potassium loss.
What to do
Monitor serum potassium, especially in patients with severe COPD, hypoxia or other risk factors. Replace potassium if levels fall.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Indacaterol inhaled?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Indacaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indacaterol, a long-acting beta-2 agonist, can lower serum potassium and may add to potassium loss from hydrochlorothiazide. At higher doses this may contribute to hypokalemia and electrocardiographic changes.
How serious is the interaction between Captopril-hydrochlorothiazide and Indacaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially in patients with severe COPD, hypoxia or other risk factors. Replace potassium if levels fall.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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