Drug interactions
Captopril-hydrochlorothiazide + Insulin detemir
Severity: Moderate
Captopril-hydrochlorothiazide and Insulin detemir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may increase insulin sensitivity and can enhance the glucose-lowering effect of insulin, occasionally causing hypoglycemia. The thiazide component can raise glucose and partly offset this.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Insulin detemir belongs to Endocrine.
Why it happens
ACE inhibition improves insulin sensitivity, while thiazides impair glucose tolerance, producing variable pharmacodynamic effects on glycemia.
What to do
Monitor blood glucose more frequently when starting, stopping or changing doses. Adjust insulin dosage as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Captopril-hydrochlorothiazide and Insulin detemir, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Insulin detemir
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Insulin detemir?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Insulin detemir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may increase insulin sensitivity and can enhance the glucose-lowering effect of insulin, occasionally causing hypoglycemia. The thiazide component can raise glucose and partly offset this.
How serious is the interaction between Captopril-hydrochlorothiazide and Insulin detemir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting, stopping or changing doses. Adjust insulin dosage as needed.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
