Drug interactions
Captopril-hydrochlorothiazide + Insulin nph
Severity: Moderate
Captopril-hydrochlorothiazide and Insulin nph: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Captopril may enhance the glucose-lowering effect of insulin and occasionally cause hypoglycemia, particularly early in therapy. Hydrochlorothiazide can counteract this by raising glucose, so control may be unpredictable.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Insulin nph can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibitors improve insulin sensitivity, while thiazide diuretics impair glucose tolerance.
What to do
Monitor blood glucose more frequently when starting or changing the combination and adjust the NPH insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Insulin nph?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Insulin nph can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Captopril may enhance the glucose-lowering effect of insulin and occasionally cause hypoglycemia, particularly early in therapy. Hydrochlorothiazide can counteract this by raising glucose, so control may be unpredictable.
How serious is the interaction between Captopril-hydrochlorothiazide and Insulin nph?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more frequently when starting or changing the combination and adjust the NPH insulin dose as needed.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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