Drug interactions
Captopril-hydrochlorothiazide + Insulin regular human
Severity: Moderate
Captopril-hydrochlorothiazide and Insulin regular human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Captopril can increase insulin sensitivity and the risk of hypoglycemia with regular insulin. Hydrochlorothiazide may partly offset this by causing hyperglycemia, making glycemic response variable.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibitors enhance insulin sensitivity, while thiazides impair glucose tolerance.
What to do
Monitor blood glucose when starting, stopping or adjusting either drug and titrate the insulin dose to the readings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Insulin regular human?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Insulin regular human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Captopril can increase insulin sensitivity and the risk of hypoglycemia with regular insulin. Hydrochlorothiazide may partly offset this by causing hyperglycemia, making glycemic response variable.
How serious is the interaction between Captopril-hydrochlorothiazide and Insulin regular human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting, stopping or adjusting either drug and titrate the insulin dose to the readings.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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