Drug interactions
Captopril-hydrochlorothiazide + Iron dextran complex
Severity: Major
Captopril-hydrochlorothiazide and Iron dextran complex: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reports suggest that patients on ACE inhibitors may have more frequent or severe anaphylactoid reactions to parenteral iron dextran. Hypotension and hypersensitivity reactions could be harder to manage.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Iron dextran complex can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Not clearly established; ACE inhibition may impair compensation for hypersensitivity-related hypotension through reduced angiotensin II and bradykinin accumulation.
What to do
Prefer a non-dextran intravenous iron formulation, or consider holding the ACE inhibitor if iron dextran is essential; give a test dose and have resuscitation equipment available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Iron dextran complex?
MediHelp rates the interaction as major. Captopril-hydrochlorothiazide and Iron dextran complex can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Reports suggest that patients on ACE inhibitors may have more frequent or severe anaphylactoid reactions to parenteral iron dextran. Hypotension and hypersensitivity reactions could be harder to manage.
How serious is the interaction between Captopril-hydrochlorothiazide and Iron dextran complex?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-dextran intravenous iron formulation, or consider holding the ACE inhibitor if iron dextran is essential; give a test dose and have resuscitation equipment available.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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