Drug interactions
Captopril-hydrochlorothiazide + Magnesium chloride
Severity: Minor
Captopril-hydrochlorothiazide and Magnesium chloride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide increases urinary magnesium loss, which can reduce the benefit of magnesium supplementation and cause hypomagnesemia over time. This is clinically relevant mainly with long-term use.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Magnesium chloride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide-induced increase in renal magnesium excretion.
What to do
Check serum magnesium periodically in long-term thiazide users and adjust supplementation as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Magnesium chloride?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Magnesium chloride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide increases urinary magnesium loss, which can reduce the benefit of magnesium supplementation and cause hypomagnesemia over time. This is clinically relevant mainly with long-term use.
How serious is the interaction between Captopril-hydrochlorothiazide and Magnesium chloride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum magnesium periodically in long-term thiazide users and adjust supplementation as needed.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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