Drug interactions
Captopril-hydrochlorothiazide + Magnesium salicylate
Severity: Moderate
Captopril-hydrochlorothiazide and Magnesium salicylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium salicylate is an NSAID-type salicylate that can reduce the antihypertensive and diuretic effects of captopril and hydrochlorothiazide. The combination also increases the risk of acute kidney injury, especially in older or volume-depleted patients. Hyperkalemia may also occur.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Magnesium salicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis reduces renal perfusion and opposes ACE inhibitor and diuretic effects.
What to do
Monitor blood pressure, renal function and potassium, and keep hydration adequate. Consider an alternative analgesic such as paracetamol where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Captopril-hydrochlorothiazide and Magnesium salicylate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Magnesium salicylate?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Magnesium salicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium salicylate is an NSAID-type salicylate that can reduce the antihypertensive and diuretic effects of captopril and hydrochlorothiazide. The combination also increases the risk of acute kidney injury, especially in older or volume-depleted patients. Hyperkalemia may also occur.
How serious is the interaction between Captopril-hydrochlorothiazide and Magnesium salicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium, and keep hydration adequate. Consider an alternative analgesic such as paracetamol where possible.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
