Drug interactions
Captopril-hydrochlorothiazide + Metformin
Severity: Moderate
Captopril-hydrochlorothiazide and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance insulin sensitivity and occasionally lower blood glucose in patients on antidiabetic drugs. Thiazides can raise glucose and may impair renal function, which increases metformin accumulation and the risk of lactic acidosis.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Metformin belongs to Endocrine.
Why it happens
ACE inhibition can improve glucose handling, while thiazide diuretics oppose glycemic control and volume depletion or reduced renal function can lower metformin clearance.
What to do
Monitor blood glucose and renal function regularly, and adjust metformin dose if eGFR declines. Hold metformin during dehydration or acute kidney injury.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Metformin
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Metformin?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may enhance insulin sensitivity and occasionally lower blood glucose in patients on antidiabetic drugs. Thiazides can raise glucose and may impair renal function, which increases metformin accumulation and the risk of lactic acidosis.
How serious is the interaction between Captopril-hydrochlorothiazide and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function regularly, and adjust metformin dose if eGFR declines. Hold metformin during dehydration or acute kidney injury.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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