Drug interactions
Captopril-hydrochlorothiazide + Mipomersen
Severity: Minor
Captopril-hydrochlorothiazide and Mipomersen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen can raise liver enzymes and cause hepatic fat accumulation. Captopril rarely causes liver injury, so the combination offers a small additive concern.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Mipomersen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive potential hepatotoxicity; no pharmacokinetic interaction is established.
What to do
Follow mipomersen liver function monitoring requirements and investigate any elevations for other contributing drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Mipomersen?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Mipomersen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mipomersen can raise liver enzymes and cause hepatic fat accumulation. Captopril rarely causes liver injury, so the combination offers a small additive concern.
How serious is the interaction between Captopril-hydrochlorothiazide and Mipomersen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow mipomersen liver function monitoring requirements and investigate any elevations for other contributing drugs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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