Drug interactions
Captopril-hydrochlorothiazide + Mycophenolate
Severity: Minor
Captopril-hydrochlorothiazide and Mycophenolate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide may compete with the mycophenolic acid glucuronide for renal tubular secretion, possibly increasing levels of the metabolite. The clinical impact is uncertain and probably small.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular anionic transport between thiazide and mycophenolic acid glucuronide.
What to do
No routine adjustment; monitor for mycophenolate adverse effects such as cytopenias and gastrointestinal symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Mycophenolate?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Mycophenolate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Hydrochlorothiazide may compete with the mycophenolic acid glucuronide for renal tubular secretion, possibly increasing levels of the metabolite. The clinical impact is uncertain and probably small.
How serious is the interaction between Captopril-hydrochlorothiazide and Mycophenolate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor for mycophenolate adverse effects such as cytopenias and gastrointestinal symptoms.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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