Drug interactions
Captopril-hydrochlorothiazide + Nitroglycerin po
Severity: Moderate
Captopril-hydrochlorothiazide and Nitroglycerin po: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrates and antihypertensives both lower blood pressure. Combining them can cause additive hypotension, dizziness or syncope, particularly when standing.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Nitroglycerin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive vasodilation from nitric oxide donation plus ACE inhibition and diuretic volume reduction.
What to do
Monitor blood pressure and warn about orthostatic symptoms; reduce the antihypertensive or nitrate dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Nitroglycerin po?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Nitroglycerin po can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitrates and antihypertensives both lower blood pressure. Combining them can cause additive hypotension, dizziness or syncope, particularly when standing.
How serious is the interaction between Captopril-hydrochlorothiazide and Nitroglycerin po?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and warn about orthostatic symptoms; reduce the antihypertensive or nitrate dose if hypotension occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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