Drug interactions
Captopril-hydrochlorothiazide + Olanzapine
Severity: Moderate
Captopril-hydrochlorothiazide and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olanzapine can cause orthostatic hypotension through alpha-1 blockade, which may add to the effect of captopril and hydrochlorothiazide. This can lead to dizziness, syncope and falls, particularly in older patients.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Olanzapine belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from alpha-adrenergic blockade and ACE inhibition plus diuresis.
What to do
Monitor orthostatic blood pressure when starting or increasing olanzapine. Reduce antihypertensive doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Olanzapine
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Olanzapine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Olanzapine can cause orthostatic hypotension through alpha-1 blockade, which may add to the effect of captopril and hydrochlorothiazide. This can lead to dizziness, syncope and falls, particularly in older patients.
How serious is the interaction between Captopril-hydrochlorothiazide and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when starting or increasing olanzapine. Reduce antihypertensive doses if symptomatic hypotension occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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