Drug interactions
Captopril-hydrochlorothiazide + Olodaterol inhaled
Severity: Moderate
Captopril-hydrochlorothiazide and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hydrochlorothiazide can cause potassium loss, and beta-2 agonists such as olodaterol can shift potassium into cells. Together they may produce hypokalemia, which is more likely at high doses and may predispose to arrhythmias. The captopril component partly offsets potassium loss.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from thiazide renal potassium wasting and beta-2 mediated intracellular potassium shift.
What to do
Monitor serum potassium, especially at initiation, in patients with heart disease or at risk of arrhythmia. Replace potassium if levels are low.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hydrochlorothiazide can cause potassium loss, and beta-2 agonists such as olodaterol can shift potassium into cells. Together they may produce hypokalemia, which is more likely at high doses and may predispose to arrhythmias. The captopril component partly offsets potassium loss.
How serious is the interaction between Captopril-hydrochlorothiazide and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially at initiation, in patients with heart disease or at risk of arrhythmia. Replace potassium if levels are low.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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