Drug interactions
Captopril-hydrochlorothiazide + Parecoxib
Severity: Moderate
Captopril-hydrochlorothiazide and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as parecoxib (a COX-2 inhibitor prodrug) can reduce the antihypertensive effect of ACE inhibitors and thiazides. They also increase the risk of acute kidney injury, particularly with volume depletion or in older patients, and may raise potassium.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis causes sodium and water retention and reduces renal perfusion, opposing ACE inhibitor and diuretic effects.
What to do
Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Use the lowest effective parecoxib dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Parecoxib?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as parecoxib (a COX-2 inhibitor prodrug) can reduce the antihypertensive effect of ACE inhibitors and thiazides. They also increase the risk of acute kidney injury, particularly with volume depletion or in older patients, and may raise potassium.
How serious is the interaction between Captopril-hydrochlorothiazide and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum creatinine and potassium, and ensure adequate hydration. Use the lowest effective parecoxib dose for the shortest time.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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