Drug interactions
Captopril-hydrochlorothiazide + Penbutolol
Severity: Minor
Captopril-hydrochlorothiazide and Penbutolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a beta-blocker with an ACE inhibitor and a thiazide is a common antihypertensive regimen, and the effects on blood pressure are additive. Hypotension and bradycardia may occur, and thiazide-related metabolic changes may be altered.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Penbutolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive blood pressure lowering through different mechanisms; beta-blockade may modestly raise potassium.
What to do
Monitor blood pressure, heart rate and serum potassium when starting or adjusting therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Penbutolol?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Penbutolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Combining a beta-blocker with an ACE inhibitor and a thiazide is a common antihypertensive regimen, and the effects on blood pressure are additive. Hypotension and bradycardia may occur, and thiazide-related metabolic changes may be altered.
How serious is the interaction between Captopril-hydrochlorothiazide and Penbutolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium when starting or adjusting therapy.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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