Drug interactions
Captopril-hydrochlorothiazide + Pentobarbital
Severity: Moderate
Captopril-hydrochlorothiazide and Pentobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital can enhance the blood pressure lowering of captopril and hydrochlorothiazide, leading to hypotension or orthostatic dizziness. The risk is greater in volume-depleted or elderly patients.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from CNS depression and vasodilation combined with antihypertensive action.
What to do
Monitor blood pressure and counsel patients about orthostatic symptoms. Reduce the antihypertensive dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Pentobarbital?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Pentobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital can enhance the blood pressure lowering of captopril and hydrochlorothiazide, leading to hypotension or orthostatic dizziness. The risk is greater in volume-depleted or elderly patients.
How serious is the interaction between Captopril-hydrochlorothiazide and Pentobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and counsel patients about orthostatic symptoms. Reduce the antihypertensive dose if hypotension develops.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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