Drug interactions
Captopril-hydrochlorothiazide + Pindolol
Severity: Minor
Captopril-hydrochlorothiazide and Pindolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pindolol combined with an ACE inhibitor and thiazide gives additive blood pressure lowering, and bradycardia or hypotension may occur. Pindolol may modestly raise potassium while hydrochlorothiazide lowers it, so the net effect is usually small.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Pindolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antihypertensive effects through different mechanisms, with opposing minor effects on serum potassium.
What to do
Monitor blood pressure, heart rate and serum potassium when starting or changing doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Pindolol?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Pindolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pindolol combined with an ACE inhibitor and thiazide gives additive blood pressure lowering, and bradycardia or hypotension may occur. Pindolol may modestly raise potassium while hydrochlorothiazide lowers it, so the net effect is usually small.
How serious is the interaction between Captopril-hydrochlorothiazide and Pindolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and serum potassium when starting or changing doses.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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