Drug interactions
Captopril-hydrochlorothiazide + Promazine
Severity: Moderate
Captopril-hydrochlorothiazide and Promazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines such as promazine can cause orthostatic hypotension through alpha-adrenergic blockade. Together with an ACE inhibitor and a thiazide, the blood pressure lowering may be enhanced, particularly in older patients.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects via alpha-blockade from promazine and the antihypertensive actions of captopril and hydrochlorothiazide.
What to do
Monitor blood pressure and orthostatic symptoms when starting or increasing promazine, and reduce the antihypertensive dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Promazine?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Promazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines such as promazine can cause orthostatic hypotension through alpha-adrenergic blockade. Together with an ACE inhibitor and a thiazide, the blood pressure lowering may be enhanced, particularly in older patients.
How serious is the interaction between Captopril-hydrochlorothiazide and Promazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or increasing promazine, and reduce the antihypertensive dose if hypotension occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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