Drug interactions
Captopril-hydrochlorothiazide + Reishi
Severity: Minor
Captopril-hydrochlorothiazide and Reishi: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Reishi mushroom has been reported to have mild blood pressure lowering activity. In theory it could add to the effect of an ACE inhibitor and thiazide, though clinical data are scarce.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Reishi have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive hypotensive effect; mechanism of reishi's action on blood pressure is not well established.
What to do
Advise the patient to report use of reishi and monitor blood pressure if it is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Reishi?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Reishi have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Reishi mushroom has been reported to have mild blood pressure lowering activity. In theory it could add to the effect of an ACE inhibitor and thiazide, though clinical data are scarce.
How serious is the interaction between Captopril-hydrochlorothiazide and Reishi?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise the patient to report use of reishi and monitor blood pressure if it is started or stopped.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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