Drug interactions
Captopril-hydrochlorothiazide + Remifentanil
Severity: Moderate
Captopril-hydrochlorothiazide and Remifentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Remifentanil can cause hypotension and bradycardia, and during anesthesia this may be amplified in patients taking an ACE inhibitor and a diuretic. Hypotension may be more pronounced and harder to correct.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Remifentanil belongs to Musculoskeletal.
Why it happens
Additive hypotensive effects from opioid-induced vasodilation and bradycardia plus ACE inhibition and diuretic-related volume depletion.
What to do
Monitor blood pressure and heart rate continuously during remifentanil use and ensure adequate volume status. Be ready to treat hypotension with fluids or vasopressors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Captopril-hydrochlorothiazide and Remifentanil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Remifentanil?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Remifentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Remifentanil can cause hypotension and bradycardia, and during anesthesia this may be amplified in patients taking an ACE inhibitor and a diuretic. Hypotension may be more pronounced and harder to correct.
How serious is the interaction between Captopril-hydrochlorothiazide and Remifentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate continuously during remifentanil use and ensure adequate volume status. Be ready to treat hypotension with fluids or vasopressors.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
