Drug interactions
Captopril-hydrochlorothiazide + Salicylates
Severity: Moderate
Captopril-hydrochlorothiazide and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-aspirin salicylates may reduce antihypertensive effects and affect renal function when combined with an ACE inhibitor and diuretic, especially at higher doses. Risk of renal impairment is greater with volume depletion.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of renal prostaglandin synthesis can cause sodium retention and decrease renal perfusion.
What to do
Monitor blood pressure, renal function and potassium with regular or high-dose salicylate use. Ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Salicylates?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-aspirin salicylates may reduce antihypertensive effects and affect renal function when combined with an ACE inhibitor and diuretic, especially at higher doses. Risk of renal impairment is greater with volume depletion.
How serious is the interaction between Captopril-hydrochlorothiazide and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and potassium with regular or high-dose salicylate use. Ensure adequate hydration.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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