Drug interactions
Captopril-hydrochlorothiazide + Salsalate
Severity: Moderate
Captopril-hydrochlorothiazide and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a non-acetylated salicylate with weaker effects on renal prostaglandins than most NSAIDs, so the interaction is probably smaller. Higher doses may nonetheless blunt antihypertensive effects and affect renal function.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate-related reduction in renal prostaglandin synthesis may lower renal perfusion and oppose blood pressure control.
What to do
Monitor blood pressure and serum creatinine when starting or adjusting salsalate, and ensure hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Salsalate?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a non-acetylated salicylate with weaker effects on renal prostaglandins than most NSAIDs, so the interaction is probably smaller. Higher doses may nonetheless blunt antihypertensive effects and affect renal function.
How serious is the interaction between Captopril-hydrochlorothiazide and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum creatinine when starting or adjusting salsalate, and ensure hydration.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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