Drug interactions
Captopril-hydrochlorothiazide + Shark cartilage
Severity: Minor
Captopril-hydrochlorothiazide and Shark cartilage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Shark cartilage supplements contain calcium and have been associated with hypercalcemia. Thiazides reduce urinary calcium excretion, so the combination could theoretically increase serum calcium.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Shark cartilage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Calcium load combined with thiazide-reduced renal calcium excretion; evidence is theoretical.
What to do
Check serum calcium if the supplement is used long term, and stop it if hypercalcemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Shark cartilage?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Shark cartilage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Shark cartilage supplements contain calcium and have been associated with hypercalcemia. Thiazides reduce urinary calcium excretion, so the combination could theoretically increase serum calcium.
How serious is the interaction between Captopril-hydrochlorothiazide and Shark cartilage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum calcium if the supplement is used long term, and stop it if hypercalcemia occurs.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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