Drug interactions
Captopril-hydrochlorothiazide + Sildenafil
Severity: Moderate
Captopril-hydrochlorothiazide and Sildenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sildenafil causes vasodilation and modest blood pressure reduction, which adds to the effect of captopril and hydrochlorothiazide. Symptomatic hypotension is possible, particularly with several antihypertensives.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Sildenafil belongs to Genitourinary.
Why it happens
Additive vasodilatory and hypotensive effects via PDE5 inhibition.
What to do
Start sildenafil at a low dose and monitor blood pressure. Advise patients to report dizziness or fainting.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Captopril-hydrochlorothiazide and Sildenafil, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Sildenafil?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sildenafil causes vasodilation and modest blood pressure reduction, which adds to the effect of captopril and hydrochlorothiazide. Symptomatic hypotension is possible, particularly with several antihypertensives.
How serious is the interaction between Captopril-hydrochlorothiazide and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start sildenafil at a low dose and monitor blood pressure. Advise patients to report dizziness or fainting.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
