Drug interactions
Captopril-hydrochlorothiazide + Sodium bicarbonate
Severity: Minor
Captopril-hydrochlorothiazide and Sodium bicarbonate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antacids such as sodium bicarbonate may reduce captopril absorption, potentially lessening its effect. The sodium load may also oppose blood pressure control.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Sodium bicarbonate belongs to Gastrointestinal Tract.
Why it happens
Raised gastric pH may reduce captopril absorption, and sodium load causes fluid retention.
What to do
Separate sodium bicarbonate from captopril by about 2 hours and monitor blood pressure if used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Sodium bicarbonate
- Acetylsalicylic acid + Sodium bicarbonate Moderate
- Alendronate + Sodium bicarbonate Moderate
- Amantadine + Sodium bicarbonate Moderate
- Carbonyl iron + Sodium bicarbonate Moderate
- Cefditoren + Sodium bicarbonate Moderate
- Cefpodoxime + Sodium bicarbonate Moderate
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Sodium bicarbonate?
MediHelp rates the interaction as minor. Captopril-hydrochlorothiazide and Sodium bicarbonate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antacids such as sodium bicarbonate may reduce captopril absorption, potentially lessening its effect. The sodium load may also oppose blood pressure control.
How serious is the interaction between Captopril-hydrochlorothiazide and Sodium bicarbonate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate sodium bicarbonate from captopril by about 2 hours and monitor blood pressure if used regularly.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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