Drug interactions
Captopril-hydrochlorothiazide + Sodium phosphates
Severity: Major
Captopril-hydrochlorothiazide and Sodium phosphates: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors and diuretics can reduce renal perfusion, and sodium phosphate preparations, especially bowel-cleansing regimens, carry a risk of acute phosphate nephropathy. The combination increases the risk of kidney injury and electrolyte disturbance.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Sodium phosphates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive renal hemodynamic compromise and volume depletion that predisposes to phosphate nephropathy.
What to do
Avoid sodium phosphate bowel preparations in patients on ACE inhibitors and diuretics, using an alternative such as polyethylene glycol; if necessary, ensure hydration and monitor renal function and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Sodium phosphates?
MediHelp rates the interaction as major. Captopril-hydrochlorothiazide and Sodium phosphates can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. ACE inhibitors and diuretics can reduce renal perfusion, and sodium phosphate preparations, especially bowel-cleansing regimens, carry a risk of acute phosphate nephropathy. The combination increases the risk of kidney injury and electrolyte disturbance.
How serious is the interaction between Captopril-hydrochlorothiazide and Sodium phosphates?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid sodium phosphate bowel preparations in patients on ACE inhibitors and diuretics, using an alternative such as polyethylene glycol; if necessary, ensure hydration and monitor renal function and electrolytes.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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