Drug interactions
Captopril-hydrochlorothiazide + Squill
Severity: Major
Captopril-hydrochlorothiazide and Squill: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Squill contains cardiac glycosides, whose toxicity is increased by hypokalemia and hypomagnesemia. Hydrochlorothiazide can cause both, raising the risk of arrhythmia.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Squill can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Diuretic-induced potassium and magnesium depletion sensitizes the myocardium to cardiac glycoside toxicity.
What to do
Avoid the combination if possible; otherwise monitor serum potassium and magnesium and correct deficits promptly, with ECG monitoring for arrhythmias.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Squill?
MediHelp rates the interaction as major. Captopril-hydrochlorothiazide and Squill can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Squill contains cardiac glycosides, whose toxicity is increased by hypokalemia and hypomagnesemia. Hydrochlorothiazide can cause both, raising the risk of arrhythmia.
How serious is the interaction between Captopril-hydrochlorothiazide and Squill?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise monitor serum potassium and magnesium and correct deficits promptly, with ECG monitoring for arrhythmias.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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