Drug interactions
Captopril-hydrochlorothiazide + Synthetic human angiotensin ii
Severity: Moderate
Captopril-hydrochlorothiazide and Synthetic human angiotensin ii: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may enhance the pressor response to exogenous angiotensin II because angiotensin II production is already reduced and receptors are upregulated. Patients on these drugs may need lower starting doses of angiotensin II.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
ACE inhibition lowers endogenous angiotensin II, producing increased sensitivity to infused angiotensin II.
What to do
Start angiotensin II at the low end of the dosing range and titrate to mean arterial pressure with continuous monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Synthetic human angiotensin ii?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Synthetic human angiotensin ii can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may enhance the pressor response to exogenous angiotensin II because angiotensin II production is already reduced and receptors are upregulated. Patients on these drugs may need lower starting doses of angiotensin II.
How serious is the interaction between Captopril-hydrochlorothiazide and Synthetic human angiotensin ii?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start angiotensin II at the low end of the dosing range and titrate to mean arterial pressure with continuous monitoring.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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