Drug interactions
Captopril-hydrochlorothiazide + Terbutaline
Severity: Moderate
Captopril-hydrochlorothiazide and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Terbutaline and hydrochlorothiazide can both lower serum potassium, so hypokalemia may be amplified. This may provoke arrhythmias, particularly with high-dose or repeated beta-agonist use.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Captopril-hydrochlorothiazide belongs to Cardiovascular; Terbutaline belongs to Respiratory.
Why it happens
Additive hypokalemia from beta-2 agonist potassium shift into cells and thiazide renal potassium loss.
What to do
Monitor serum potassium in patients receiving frequent or high-dose terbutaline. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Other interactions of Terbutaline
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Terbutaline?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Terbutaline and hydrochlorothiazide can both lower serum potassium, so hypokalemia may be amplified. This may provoke arrhythmias, particularly with high-dose or repeated beta-agonist use.
How serious is the interaction between Captopril-hydrochlorothiazide and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients receiving frequent or high-dose terbutaline. Replace potassium as needed.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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