Drug interactions
Captopril-hydrochlorothiazide + Xipamide
Severity: Moderate
Captopril-hydrochlorothiazide and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xipamide is a thiazide-like diuretic, so combining it with hydrochlorothiazide duplicates therapy and increases diuresis. This raises the risk of hypokalemia, hyponatremia, volume depletion and renal impairment.
What this interaction means in plain words
Captopril-hydrochlorothiazide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of renal sodium chloride reabsorption in the distal tubule.
What to do
Avoid duplicate thiazide-type therapy where possible. If combined, monitor electrolytes, renal function and volume status.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Captopril-hydrochlorothiazide
- Aliskiren + Captopril-hydrochlorothiazide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aceclofenac + Captopril-hydrochlorothiazide Major
- Aldesleukin + Captopril-hydrochlorothiazide Major
- Amifostine + Captopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Captopril-hydrochlorothiazide with Xipamide?
MediHelp rates the interaction as moderate. Captopril-hydrochlorothiazide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xipamide is a thiazide-like diuretic, so combining it with hydrochlorothiazide duplicates therapy and increases diuresis. This raises the risk of hypokalemia, hyponatremia, volume depletion and renal impairment.
How serious is the interaction between Captopril-hydrochlorothiazide and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate thiazide-type therapy where possible. If combined, monitor electrolytes, renal function and volume status.
What other medicines interact with Captopril-hydrochlorothiazide?
MediHelp also lists interactions of Captopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sacubitril / valsartan. The full list is on the Captopril-hydrochlorothiazide page.
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