Drug interactions
Carbenoxolone + Celecoxib
Severity: Moderate
Carbenoxolone and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like effects causing sodium and fluid retention and potassium loss, and NSAIDs also cause fluid retention. Together they may worsen hypertension, edema and heart failure, while the net effect on potassium is unclear.
What this interaction means in plain words
Carbenoxolone and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sodium and water retention from carbenoxolone mineralocorticoid-like action and NSAID prostaglandin inhibition.
What to do
Monitor blood pressure, weight, edema and serum potassium. Avoid in patients with heart failure or uncontrolled hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Carbenoxolone with Celecoxib?
MediHelp rates the interaction as moderate. Carbenoxolone and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like effects causing sodium and fluid retention and potassium loss, and NSAIDs also cause fluid retention. Together they may worsen hypertension, edema and heart failure, while the net effect on potassium is unclear.
How serious is the interaction between Carbenoxolone and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight, edema and serum potassium. Avoid in patients with heart failure or uncontrolled hypertension.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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