Drug interactions
Carbenoxolone + Etodolac
Severity: Moderate
Carbenoxolone and Etodolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone causes sodium and fluid retention with potassium loss, and NSAIDs also cause fluid retention, so blood pressure and edema may worsen. Carbenoxolone is used for ulcer protection, so the combination is of limited rationale.
What this interaction means in plain words
Carbenoxolone and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone's mineralocorticoid-like effect combined with NSAID renal sodium retention produces additive fluid retention and hypertension.
What to do
Monitor blood pressure, edema, and serum potassium; avoid in patients with heart failure, hypertension, or renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Carbenoxolone with Etodolac?
MediHelp rates the interaction as moderate. Carbenoxolone and Etodolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone causes sodium and fluid retention with potassium loss, and NSAIDs also cause fluid retention, so blood pressure and edema may worsen. Carbenoxolone is used for ulcer protection, so the combination is of limited rationale.
How serious is the interaction between Carbenoxolone and Etodolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema, and serum potassium; avoid in patients with heart failure, hypertension, or renal impairment.
What other medicines interact with Etodolac?
MediHelp also lists interactions of Etodolac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Etodolac page.
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