Drug interactions
Carbenoxolone + Fosinopril-hydrochlorothiazide
Severity: Major
Carbenoxolone and Fosinopril-hydrochlorothiazide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity that causes sodium retention and potassium loss. With a thiazide, hypokalemia can be pronounced and fluid retention may counteract antihypertensive therapy.
What this interaction means in plain words
Carbenoxolone and Fosinopril-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of 11-beta-hydroxysteroid dehydrogenase causes mineralocorticoid excess, adding to thiazide potassium wasting.
What to do
Avoid the combination where possible. If used, monitor serum potassium and blood pressure closely and supplement potassium as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Frequently asked questions
Can I take Carbenoxolone with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as major. Carbenoxolone and Fosinopril-hydrochlorothiazide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbenoxolone has mineralocorticoid-like activity that causes sodium retention and potassium loss. With a thiazide, hypokalemia can be pronounced and fluid retention may counteract antihypertensive therapy.
How serious is the interaction between Carbenoxolone and Fosinopril-hydrochlorothiazide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor serum potassium and blood pressure closely and supplement potassium as needed.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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