Drug interactions
Carbenoxolone + Hydrochlorothiazide-losartan
Severity: Major
Carbenoxolone and Hydrochlorothiazide-losartan: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone causes sodium retention and potassium loss, and together with hydrochlorothiazide may produce marked hypokalemia and fluid retention that opposes blood pressure control. Losartan only partly offsets this.
What this interaction means in plain words
Carbenoxolone and Hydrochlorothiazide-losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Carbenoxolone has mineralocorticoid-like activity by inhibiting 11-beta-hydroxysteroid dehydrogenase, adding to thiazide potassium wasting.
What to do
Avoid the combination if possible. If used, monitor serum potassium, blood pressure and fluid status closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Frequently asked questions
Can I take Carbenoxolone with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as major. Carbenoxolone and Hydrochlorothiazide-losartan can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carbenoxolone causes sodium retention and potassium loss, and together with hydrochlorothiazide may produce marked hypokalemia and fluid retention that opposes blood pressure control. Losartan only partly offsets this.
How serious is the interaction between Carbenoxolone and Hydrochlorothiazide-losartan?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, monitor serum potassium, blood pressure and fluid status closely.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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