Drug interactions
Carbenoxolone + Indomethacin
Severity: Moderate
Carbenoxolone and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone causes sodium and water retention and potassium loss, and indomethacin also promotes fluid retention and can worsen blood pressure and edema. Together they may aggravate hypertension and heart failure.
What this interaction means in plain words
Carbenoxolone and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone has mineralocorticoid-like effects, and NSAIDs reduce renal prostaglandins, so sodium retention is additive.
What to do
Monitor blood pressure, edema, and serum potassium and renal function. Avoid in patients with heart failure or uncontrolled hypertension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Carbenoxolone with Indomethacin?
MediHelp rates the interaction as moderate. Carbenoxolone and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone causes sodium and water retention and potassium loss, and indomethacin also promotes fluid retention and can worsen blood pressure and edema. Together they may aggravate hypertension and heart failure.
How serious is the interaction between Carbenoxolone and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, edema, and serum potassium and renal function. Avoid in patients with heart failure or uncontrolled hypertension.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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