Drug interactions
Carbenoxolone + Ipratropium-salbutamol
Severity: Moderate
Carbenoxolone and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone causes mineralocorticoid-like potassium loss and salbutamol drives potassium into cells, so combined use can produce marked hypokalemia. This raises the risk of arrhythmia, especially with high-dose salbutamol.
What this interaction means in plain words
Carbenoxolone and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from renal potassium wasting and beta-2 agonist-induced intracellular potassium shift.
What to do
Monitor serum potassium regularly and replace as required. Avoid prolonged combined use where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Frequently asked questions
Can I take Carbenoxolone with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Carbenoxolone and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone causes mineralocorticoid-like potassium loss and salbutamol drives potassium into cells, so combined use can produce marked hypokalemia. This raises the risk of arrhythmia, especially with high-dose salbutamol.
How serious is the interaction between Carbenoxolone and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium regularly and replace as required. Avoid prolonged combined use where possible.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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