Drug interactions
Carbenoxolone + Irbesartan
Severity: Moderate
Carbenoxolone and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity causing sodium and water retention and potassium loss, which can offset irbesartan's blood pressure and potassium effects. Hypertension and hypokalemia can result with carbenoxolone alone, and the net effect with irbesartan is unpredictable.
What this interaction means in plain words
Carbenoxolone and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of 11-beta-hydroxysteroid dehydrogenase produces mineralocorticoid excess, opposing angiotensin receptor blockade.
What to do
Monitor blood pressure and serum potassium during concurrent use. Consider an alternative to carbenoxolone if blood pressure control is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Carbenoxolone with Irbesartan?
MediHelp rates the interaction as moderate. Carbenoxolone and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like activity causing sodium and water retention and potassium loss, which can offset irbesartan's blood pressure and potassium effects. Hypertension and hypokalemia can result with carbenoxolone alone, and the net effect with irbesartan is unpredictable.
How serious is the interaction between Carbenoxolone and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium during concurrent use. Consider an alternative to carbenoxolone if blood pressure control is lost.
What other medicines interact with Irbesartan?
MediHelp also lists interactions of Irbesartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Irbesartan page.
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