Drug interactions
Carbenoxolone + Ketoprofen
Severity: Moderate
Carbenoxolone and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone causes sodium retention and potassium loss through mineralocorticoid-like effects, and NSAIDs also cause fluid retention and may worsen blood pressure and edema. The potassium effect of the pair is unpredictable.
What this interaction means in plain words
Carbenoxolone and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone has mineralocorticoid activity causing potassium wasting, while NSAIDs inhibit prostaglandin-mediated renal sodium excretion.
What to do
Monitor blood pressure, fluid status and serum potassium during co-use. Consider an alternative analgesic in patients with hypertension or heart failure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carbenoxolone and Ketoprofen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Carbenoxolone with Ketoprofen?
MediHelp rates the interaction as moderate. Carbenoxolone and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone causes sodium retention and potassium loss through mineralocorticoid-like effects, and NSAIDs also cause fluid retention and may worsen blood pressure and edema. The potassium effect of the pair is unpredictable.
How serious is the interaction between Carbenoxolone and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and serum potassium during co-use. Consider an alternative analgesic in patients with hypertension or heart failure.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
