Drug interactions
Carbenoxolone + Nadolol
Severity: Moderate
Carbenoxolone and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like activity that causes sodium and fluid retention and potassium loss, which can raise blood pressure and counteract the antihypertensive effect of nadolol. Hypokalemia may also increase arrhythmia risk in patients with cardiac disease.
What this interaction means in plain words
Carbenoxolone and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism through carbenoxolone-induced mineralocorticoid effects (sodium retention, hypokalemia) opposing beta-blocker blood pressure lowering.
What to do
Monitor blood pressure and serum potassium regularly during combined use. Correct hypokalemia and reassess nadolol dosing if blood pressure control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
Frequently asked questions
Can I take Carbenoxolone with Nadolol?
MediHelp rates the interaction as moderate. Carbenoxolone and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like activity that causes sodium and fluid retention and potassium loss, which can raise blood pressure and counteract the antihypertensive effect of nadolol. Hypokalemia may also increase arrhythmia risk in patients with cardiac disease.
How serious is the interaction between Carbenoxolone and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium regularly during combined use. Correct hypokalemia and reassess nadolol dosing if blood pressure control worsens.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Amifostine. The full list is on the Nadolol page.
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