Drug interactions
Carbenoxolone + Nebivolol
Severity: Moderate
Carbenoxolone and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like effects causing sodium and water retention, hypertension and hypokalemia. This can oppose the antihypertensive effect of nebivolol, and hypokalemia may add arrhythmia risk.
What this interaction means in plain words
Carbenoxolone and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone inhibits 11-beta-hydroxysteroid dehydrogenase, causing mineralocorticoid excess that counteracts blood pressure lowering.
What to do
Monitor blood pressure and serum potassium, and correct hypokalemia; consider stopping carbenoxolone if hypertension or fluid retention develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Frequently asked questions
Can I take Carbenoxolone with Nebivolol?
MediHelp rates the interaction as moderate. Carbenoxolone and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like effects causing sodium and water retention, hypertension and hypokalemia. This can oppose the antihypertensive effect of nebivolol, and hypokalemia may add arrhythmia risk.
How serious is the interaction between Carbenoxolone and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium, and correct hypokalemia; consider stopping carbenoxolone if hypertension or fluid retention develops.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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