Drug interactions
Carbenoxolone + Oxaprozin
Severity: Moderate
Carbenoxolone and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone causes sodium retention, hypokalemia and fluid overload with hypertension, and NSAIDs add to fluid retention and can impair renal function. The combination may worsen blood pressure and edema, and NSAIDs also counter the mucosal benefit of carbenoxolone.
What this interaction means in plain words
Carbenoxolone and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Carbenoxolone has mineralocorticoid-like effects while oxaprozin reduces renal prostaglandins, so both promote sodium and water retention.
What to do
Monitor blood pressure, weight, edema and serum potassium. Consider an alternative to one agent if fluid retention or hypertension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Carbenoxolone with Oxaprozin?
MediHelp rates the interaction as moderate. Carbenoxolone and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone causes sodium retention, hypokalemia and fluid overload with hypertension, and NSAIDs add to fluid retention and can impair renal function. The combination may worsen blood pressure and edema, and NSAIDs also counter the mucosal benefit of carbenoxolone.
How serious is the interaction between Carbenoxolone and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, weight, edema and serum potassium. Consider an alternative to one agent if fluid retention or hypertension develops.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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