Drug interactions
Carbenoxolone + Sulindac
Severity: Moderate
Carbenoxolone and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbenoxolone has mineralocorticoid-like effects causing sodium and water retention and potassium loss, which can raise blood pressure. NSAIDs also cause fluid retention and can worsen hypertension and edema, and carbenoxolone-induced hypokalemia is not reliably offset.
What this interaction means in plain words
Carbenoxolone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sodium and fluid retention (mineralocorticoid-like effect plus NSAID inhibition of renal prostaglandins).
What to do
Monitor blood pressure, fluid status and serum potassium during combined use. Use the lowest effective doses for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Carbenoxolone with Sulindac?
MediHelp rates the interaction as moderate. Carbenoxolone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbenoxolone has mineralocorticoid-like effects causing sodium and water retention and potassium loss, which can raise blood pressure. NSAIDs also cause fluid retention and can worsen hypertension and edema, and carbenoxolone-induced hypokalemia is not reliably offset.
How serious is the interaction between Carbenoxolone and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and serum potassium during combined use. Use the lowest effective doses for the shortest time.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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