Drug interactions
Carbidopa + Enalapril
Severity: Moderate
Carbidopa and Enalapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbidopa given with levodopa can contribute to orthostatic hypotension, which may add to enalapril's blood pressure lowering. Symptomatic hypotension may be seen when levodopa therapy is begun or increased.
What this interaction means in plain words
Carbidopa and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa belongs to Central Nervous System; Enalapril belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from dopaminergic therapy and ACE inhibition.
What to do
Monitor orthostatic blood pressure when starting or titrating levodopa/carbidopa and reduce enalapril if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril
- Aliskiren + Enalapril Contraindicated
- Enalapril + Protein a column Contraindicated
- Enalapril + Sacubitril / valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Amifostine + Enalapril Major
- Amiloride + Enalapril Major
Other interactions of Carbidopa
Frequently asked questions
Can I take Carbidopa with Enalapril?
MediHelp rates the interaction as moderate. Carbidopa and Enalapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carbidopa given with levodopa can contribute to orthostatic hypotension, which may add to enalapril's blood pressure lowering. Symptomatic hypotension may be seen when levodopa therapy is begun or increased.
How serious is the interaction between Carbidopa and Enalapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when starting or titrating levodopa/carbidopa and reduce enalapril if needed.
What other medicines interact with Enalapril?
MediHelp also lists interactions of Enalapril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Enalapril page.
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