Drug interactions
Carbidopa + Hydrochlorothiazide-olmesartan
Severity: Minor
Carbidopa and Hydrochlorothiazide-olmesartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carbidopa, usually given with levodopa, can add to blood pressure lowering, and orthostatic hypotension may occur with antihypertensives. Carbidopa alone has little hypotensive effect, so the interaction mainly reflects levodopa.
What this interaction means in plain words
Carbidopa and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbidopa belongs to Central Nervous System; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Additive hypotensive effect from dopaminergic therapy and antihypertensive agents.
What to do
Monitor orthostatic blood pressure when starting levodopa/carbidopa and reduce antihypertensive doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Carbidopa
Frequently asked questions
Can I take Carbidopa with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as minor. Carbidopa and Hydrochlorothiazide-olmesartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carbidopa, usually given with levodopa, can add to blood pressure lowering, and orthostatic hypotension may occur with antihypertensives. Carbidopa alone has little hypotensive effect, so the interaction mainly reflects levodopa.
How serious is the interaction between Carbidopa and Hydrochlorothiazide-olmesartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when starting levodopa/carbidopa and reduce antihypertensive doses if symptomatic hypotension occurs.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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