Drug interactions
Carbidopa-entacapone-levodopa + Cariprazine
Severity: Moderate
Carbidopa-entacapone-levodopa and Cariprazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cariprazine is a dopamine D2/D3 partial agonist that may blunt the antiparkinsonian effect of levodopa and worsen motor symptoms. Both drugs can also cause somnolence and orthostatic hypotension.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Cariprazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic opposition at dopamine D2/D3 receptors plus additive sedative and hypotensive effects.
What to do
Monitor parkinsonian motor control, sedation and orthostatic blood pressure. Consider an antipsychotic with less D2 activity if motor worsening occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Cariprazine
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Cariprazine?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Cariprazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cariprazine is a dopamine D2/D3 partial agonist that may blunt the antiparkinsonian effect of levodopa and worsen motor symptoms. Both drugs can also cause somnolence and orthostatic hypotension.
How serious is the interaction between Carbidopa-entacapone-levodopa and Cariprazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor parkinsonian motor control, sedation and orthostatic blood pressure. Consider an antipsychotic with less D2 activity if motor worsening occurs.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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