Drug interactions
Carbidopa-entacapone-levodopa + Chlorothiazide
Severity: Moderate
Carbidopa-entacapone-levodopa and Chlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, and thiazide diuretics lower blood pressure and cause volume depletion. Together they may cause dizziness and falls, particularly in older adults.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Chlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Chlorothiazide belongs to Cardiovascular.
Why it happens
Additive hypotensive effects of levodopa-related vasodilation and diuretic-induced volume depletion.
What to do
Monitor orthostatic blood pressure when starting levodopa and reduce the diuretic dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Chlorothiazide?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Chlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, and thiazide diuretics lower blood pressure and cause volume depletion. Together they may cause dizziness and falls, particularly in older adults.
How serious is the interaction between Carbidopa-entacapone-levodopa and Chlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when starting levodopa and reduce the diuretic dose if symptomatic hypotension occurs.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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