Drug interactions
Carbidopa-entacapone-levodopa + Cyclizine
Severity: Minor
Carbidopa-entacapone-levodopa and Cyclizine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine has anticholinergic properties that may modestly help parkinsonian symptoms but can add to confusion, hallucinations and dyskinesia in susceptible patients. High anticholinergic burden can slow gastric emptying and delay levodopa absorption.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Cyclizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Cyclizine belongs to Respiratory.
Why it happens
Additive anticholinergic effects with possible delayed gastric emptying reducing levodopa absorption.
What to do
Monitor for confusion, hallucinations and changes in motor response, especially in older patients. Use the lowest effective cyclizine dose and avoid prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carbidopa-entacapone-levodopa and Cyclizine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Cyclizine?
MediHelp rates the interaction as minor. Carbidopa-entacapone-levodopa and Cyclizine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclizine has anticholinergic properties that may modestly help parkinsonian symptoms but can add to confusion, hallucinations and dyskinesia in susceptible patients. High anticholinergic burden can slow gastric emptying and delay levodopa absorption.
How serious is the interaction between Carbidopa-entacapone-levodopa and Cyclizine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for confusion, hallucinations and changes in motor response, especially in older patients. Use the lowest effective cyclizine dose and avoid prolonged use.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
