Drug interactions
Carbidopa-entacapone-levodopa + Felodipine
Severity: Moderate
Carbidopa-entacapone-levodopa and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa has blood pressure lowering and orthostatic effects that add to felodipine vasodilation. Dizziness, falls and syncope can result, particularly in older patients.
What this interaction means in plain words
Carbidopa-entacapone-levodopa and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbidopa-entacapone-levodopa belongs to Central Nervous System; Felodipine belongs to Cardiovascular.
Why it happens
Additive vasodilatory and hypotensive effects of levodopa and a dihydropyridine calcium channel blocker.
What to do
Monitor orthostatic blood pressure when starting or changing either drug. Reduce the felodipine dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbidopa-entacapone-levodopa
- Carbidopa-entacapone-levodopa + Isocarboxazid Contraindicated
- Carbidopa-entacapone-levodopa + Phenelzine Contraindicated
- Carbidopa-entacapone-levodopa + Selegiline transdermal Contraindicated
- Carbidopa-entacapone-levodopa + Tranylcypromine Contraindicated
- Amisulpride + Carbidopa-entacapone-levodopa Major
- Asenapine transdermal + Carbidopa-entacapone-levodopa Major
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Carbidopa-entacapone-levodopa with Felodipine?
MediHelp rates the interaction as moderate. Carbidopa-entacapone-levodopa and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa has blood pressure lowering and orthostatic effects that add to felodipine vasodilation. Dizziness, falls and syncope can result, particularly in older patients.
How serious is the interaction between Carbidopa-entacapone-levodopa and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor orthostatic blood pressure when starting or changing either drug. Reduce the felodipine dose if symptomatic hypotension occurs.
What other medicines interact with Carbidopa-entacapone-levodopa?
MediHelp also lists interactions of Carbidopa-entacapone-levodopa with, for example, Isocarboxazid, Phenelzine, Selegiline transdermal. The full list is on the Carbidopa-entacapone-levodopa page.
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